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Proton-pump inhibitors like omeprazole have been found to increase the plasma concentrations of methotrexate.

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efficacy of mifepristone mifeprex, mifepristone, ru486 and misoprostol, methotrexate and misoprostol, tamoxifen and misoprostol and misoprostol alone have a success rate ranging from 75 to 98 depending on length of pregnancy, dosages and route given, and additional techniques performed to achieve a high success rate.

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trimethoprim-sulfamethoxazole also affects renal clearance of several drugs, including methotrexate.

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these side effects can often be overcome by increasing folic acid or using an activated form of folic acid known as folinic acid leukovorin given as a 5mg dose 12 hours and sometimes 24 hours after methotrexate is given.

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